I run almost exclusively on trails; I hate running on roads now for any length of time.  Not everyone has the luxury of doing this on a daily basis, but you may have trail gems in the large city you live. The only actual cities I've ever lived in were Miami, FL and Worcester, MA.  In both, I regularly ran trails. At Barry university, there was a 1.5 mi dirt path around the entire campus, as well as the trails in Oleta River Park.  In Worcester, I ran 5 minutes down the road from St Vincent Hospital to access over 8 miles of technical hiking trails that connected  Christofo Columbo park on Shrewsbury st with Green hill park up on Belmont.  As a visitor, I've experienced trails within a few miles of urban centers in Phoenix, AZ, NYC, and Boston.  You just have to look!  
What I love most, though, is running hiking trails in mountains.  This fascination began in college in the Adirondacks. Oftentimes, there is little in the way of running going on as you face traverses, scrambling and near vertical climbs, and fields of boulders.  The idea is to move quickly, efficiently and safely across these environments.  And while standard runners may not like the disruption in running, you can experience natural human full-body movement patterns. Scrambling, climbing, jumping, are movements ingrained in our ancestral instincts, but not experienced in our suburban 5K loop.  
We had the chance last weekend to get over to the White mountains again, where I hope to take a stab at running the Presidental range traverse later in the summer.  My friend Kevin and I scoped out one of the ascents to the traverse that the current record holder took, the Daniel Webster Scout trail.  Running here is a relative term.  The trail ascends over extremely rocky and rooty terrain for 4100' in 4 miles before hitting Mount Madison, the first in the north-south presidential traverse.  
We had near perfect conditions on this trip, and I can only hope to have something similar when I return in 1-2 months.  Like always, a trip to the mountains lends to spiritual growth and mental decompression through meditation in movement and mindfulness in the simplicity physical challenge.  
That experience doesn't always have to come from a big mountain range; if that mountain is a hill in your small city or a dirt path along a chain-link fence, try running on a more natural surface! 

Just like the Standard American Diet has become known as the antithesis of healthy eating, I propose that the Standard American Footwear should also be known as the antithesis to healthy feet.  
There is no medical research to show this; obviously the shoe companies aren't clambering to do good research that may eradicate their own products.  Shoes in the developed world have been a result of fashion, and certainly not function. Modern walking surfaces were created to promote industry and cleanliness and took no consideration on the interaction of the human limb with its surface.  
Western footwear promotes musculoskeletal imbalance from their high heels and tight toeboxes. 
Western walking surfaces and daily movement patterns also encourage musculoskeletal imbalances. Sitting in chairs 40 hours per week or walking on hard flat surfaces are very unnatural musculoskeletal patterns.  
So if you do partake in a piece of SAF, do it infrequently. Recognize that your foot is another body part to strengthen and challenge.  There's no magic shoe for foot pain, like there is no magic pill for good health.  For every part of the body, exercise is key!